Enantioselective enzymatic desymmetrization of prochiral 1,3-diols and enzymatic resolution of monoprotected 1,3-diols based on α-tetralone and related multifunctional scaffolds
نویسندگان
چکیده
Article history: Received 2 October 2008 Accepted 22 October 2008 0957-4166/$ see front matter 2008 Elsevier Ltd. A doi:10.1016/j.tetasy.2008.10.024 * Corresponding author. E-mail address: [email protected] (S. N Novel multifunctional chemotypes based on a-tetralone, a-indanone, and chromanone have been synthesized by a chemo-enzymatic approach by applying an enzymatic irreversible transesterification strategy. The scaffolds synthesized can be further elaborated with subsequent enzymatic as well as chemical transformations for the generation of new sets of structurally related organic molecules. 2008 Elsevier Ltd. All rights reserved.
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تاریخ انتشار 2008